Adrenal Function After Prolonged Corticosteroid Therapy
نویسندگان
چکیده
منابع مشابه
Adrenal function during topical oral corticosteroid treatment.
Plasma cortisol (hydrocortisone) levels were measured in 42 subjects before and during administration of topical oral corticosteroids. Topical administration of 0.3-0.4 mg. of betamethasone disodium phosphate daily caused partial suppression of adrenal function in 8 out of 10 subjects tested. The adrenal function remained normal in 14 patients treated with 10 mg. of hydrocortisone hemisuccinate...
متن کاملEffect of alternate-day, single-dose, corticosteroid therapy on pituitary-adrenal function.
Therapeutic doses of ACTH given daily and maintained for more than 2 years in patients with poly-arthritis do not normally suppress hypothalamic-pituitary-adrenal (HPA) responsiveness to the stresses of insulin hypoglycaemia or surgery (Carter and James, 1970a, b). By contrast, corticosteroids in daily doses equivalent to 7 5 mg. or more of predni-solone will impair pituitary-adrenal function i...
متن کاملPituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis.
It has been known for many years that administration of corticosteroids can cause atrophy of the adrenal glands (Ingle and Kendall, 1937), and that the severity of the atrophy is proportional to the duration of administration (Salassa, Bennett, Keating, and Sprague, 1953; Bennett, 1954). Kilby, Bennett, and Sprague (1957) described degranulation of the basophil cells of the pituitary which also...
متن کاملProlonged low-dose corticosteroid therapy and osteoporosis in rheumatoid arthritis.
Thirty-one patients with rheumatoid arthritis maintained on prednisolone 5 mg daily for an average period of 9.4 years were assessed radiologically to determine the degree of osteoporosis in their spine and peripheral skeleton. They were compared with a control group of 32 rheumatoid patients who had never received corticosteroids. The steroid-treated patients had more severe osteoporosis than ...
متن کاملCorticosteroid-induced hypothalamo-pituitary-adrenal axis suppression. Prospective study using two regimens of corticosteroid therapy.
Long-term oral corticosteroid therapy leads to suppression of the hypothalamo-pituitary-adrenal (HPA) axis (Paris, 1961; Treadwell, Savage, Sever, and Copeman, 1963; Jasani, Boyle, Greig, Dalakos, Browning, Thompson, andBuchanan, 1967). Much work has been done on the influence of the regimen of corticosteroid administration on this suppression. Harter, Reddy, and Thorn (1963) have presented evi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1962
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5292.1579